Mutations in some of these shared clock genes can cause sleep disorders in people.
Mutations in some strains of influenza A virus can render the virus resistant to amantadine; however, these mutations do not appear to increase virulence.
However, this statement is based on averages, and locally, large variations or ruptures in LD pattern can be observed, because of recent mutations in some lineages, for example.
Indeed, recent data suggest shared genetic substrates and phenotypic-genotypic correlations with mutations in some ion transporters genes, including CACNA1A, ATP1A2, SCN1A [3, 4].
Interestingly, monoallelic mutations in some of the downstream proteins are known to confer a high risk of breast cancer (e.g., FANCD1 = BRCA2, FANCN = PALPB2, FANCJ = BRIP1, FANCO = RAD51C).
Although targeted resequencing utilized for the identification of causal variants has discovered coding mutations in some AD-associated genes, a lot of risk variants lie in noncoding regions.
Mutagenic libraries were designed in order to stabilize the protein introducing mutations in some of the flexible regions and residues identified.
Mutations in some of these genes can cause a pure motor form of hereditary motor neuropathy, the genetics of which are poorly characterized.
Our results indicate the accumulation of mutations in some but not all organs of the mouse with significant differences in mutational spectra.
Mutations in some genes that encode sodium channel and GABAA receptor subunits have been found in a few families affected by febrile seizures.
Disease mutations are spread over all the domains of Parkin, although mutations in some regions may affect the functionality of Parkin more adversely.
