Sentence examples for mutations in somatic from inspiring English sources
From this, we conclude the mutational processes that shaped human mitochondria over time generate de novo mtDNA mutations in somatic tissues.
However, mutations in somatic (body) cells will exert their effect only on that individual and will not be passed on to progeny.
This influence has helped shape the genomes of humans and other multicellular organisms and can affect the distribution of mutations in somatic cells.
Gene editing of CFTR mutations in somatic stem cells and induced pluripotent stem cells is also transforming gene therapy approaches for CF. This short review evaluates several areas that are key to building animal and cell systems capable of modeling CF disease and testing potential treatments.
While it is not possible to generalize because of differences in both species and cell type, it is intriguing that the association of germ line point mutations with increased cell division is in complete agreement with our results of point mutations in somatic cells being highly dependent on cell proliferation whilst rearrangements can occur in both dividing and non-dividing cell populations.
To check for evidence of mutations in somatic cells, we isolated pooled genomic DNA from 4 10 embryos for each pair of ZFNs and performed limited cycle PCR/DNA sequencing to assess whether mutations were introduced at their intended endogenous gene targets.
Cytogenetic analysis of human chromosomes in peripheral lymphocytes allows direct detection of mutation in somatic cells.
Cytogenetic analyses of human chromosomes in peripheral lymphocytes allows direct detection of mutation in somatic cells.
This assay will measure forward or reverse mutation at the wx locus in pollen grains, point mutation in somatic cells and will incorporate a cytogenetic endpoint in root-tip cells.
We tested whether ZFN-induced mutations observed in somatic zebrafish cells could be transmitted efficiently through the germline.
Using archival formalin-fixed paraffin embedded (FFPE) extracted genomic DNA, we show that c-CBL mutations occur in somatic fashion for lung cancers.
