We have developed a mutational annotation pipeline that functionally categorizes mutations in proteins.
Mutations in proteins allow functional innovation, but can be critically destabilizing.
First up for Folding@home's mobile initiatives is a project that will help study mutations in proteins targeted by drugs designed to fight breast cancer, and a project coming soon to smartphones will look at processes involved in diseases that stem from misfolding proteins, such as Alzheimer's.
In Drosophila, mutations in proteins that stabilize the actin and microtubule cytoskeletons activate the DLK pathway, suggesting that DLK may be activated by cytoskeletal disruption.
These data clearly demonstrate the importance and efficacy of the presented strategy for selection of stabilizing mutations in proteins of high intrinsic stability within reasonable time.
Meanwhile, The Washington Post also reports a new potential method of forensic analysis using hair that examines precise mutations in proteins instead of DNA.
As a basis a new selection strategy that allowed the application of yeast surface display for screening of stabilizing mutations in proteins of already high intrinsic thermal stability and Tm-values up to 85 °C was developed.
Direct methods, which use global statistical models of sequence coevolution, have enabled the prediction of membrane and disordered protein structures, protein complex architectures, and the functional effects of mutations in proteins.
They are looking at [genetic] splicing in humans in the malaria parasite Plasmodium spp. Utpal Banerjee of UCLA is running a research program looking a mutations in proteins in Drosophila eyes.
The disease is caused by several mutations in proteins integrated in the Usher protein network.
Many diseases have been associated to mutations in proteins involved in intracellular transport [10].
