Sentence examples for mutations in negative from inspiring English sources
Some of the most dramatic mutant overgrowth phenotypes identified in these screens were mutations in negative regulators of the Hippo pathway (Hpo, Sav, Wts, Crbs, Ex), whose loss simultaneously altered several cellular processes associated with tumorigenesis including increased cellular proliferation and prevention of apoptosis [6].
Loss-of-function mutations in negative regulators of this Gqα pathway including goa-1/Goα, eat-16/RGS7 and dgk-1, all lead to a hypersensitive phenotype on aldicarb [50].
Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative regulators of HIF1α.
This suggests that once the third most common pathways involving single mutations have been realized, the same evolutionary principles can be applied to double mutations starting with double mutations in negative regulators, followed by double mutations in one negative regulator and one promoter mutation.
Moreover, although mutations in negative regulatory components such as APC and Axin, are rare, loss of heterozygosity, downregulation or epigenetic silencing of these genes occurs in up to 70% of breast tumor cell lines and cancers [ 105, 108, 109, 114, 139- 152].
The high frequency of TP53 mutations in triple negative breast cancer (TNBC: negative for estrogen receptor, progesterone receptor, and HER2) make Chk1 an attractive therapeutic target.
Both K76T and A173E mutations result in negative charge shifts.
Mutations in other negative regulators of translation have also been implicated in neurodevelopmental disorders.
Exon 9 and 20 PIK3CA mutations in triple negative breast cancer specimens.
Importantly, mutations in upstream negative regulators of mTOR cause hamartomas, haemangiomas, and cancers that are sensitive to rapamycin treatment.
In our experiments this led to exceptional high reverse mutations in the negative control plates and quite week mutagenic effects in the dosed samples.
