Sentence examples for mutations in important from inspiring English sources

With its near-normal and mostly stable karyotype, a lack of cell line specific mutational processes and a lack of inactivating mutations in important DNA repair genes, it seems an excellent choice of cell line for continued research in the areas of DNA repair and related processes.

In prostate cancer, for example, his group found mutations in important genes that are not readily attacked by drugs.

Several studies have demonstrated indirect mutations in important pathways relevant to EMT.

It should be noted, however, that inherited and somatic mutations in important TSGs can be associated with different phenotypes.

The sub-types defined using expression data and methylation data demonstrate considerable congruence and are also clearly correlated with mutations in important cancer genes.

While presently there are no reports of mutations in important EMT regulators driving malignancy or disease progression, ensuing studies may clarify their involvement.

Our analysis confirms that identical, recurrent mutations of single genes are infrequent in MM, but highlights that mutations cluster in important cellular pathways.

Mutations in the important amino acid sites of these conserved domains will cause Rab proteins to produce some constitutive inhibiting or activating mutant proteins.

In newborns exposed to secondhand smoke, mutations in an important gene occur at a high rate, according to a pilot study in next month's Nature Medicine.

It found whale-specific mutations in genes important for the regulation of salt and of blood pressure and for antioxidants that get rid of charged oxygen molecules that can harm cells.

Among patients with characteristic mutations in the important tumor-suppressor gene TP53 which make people more vulnerable to cancer 84% also showed a known molecular signature of exposure to aristolochic acid, they found.