Sentence examples for mutations in general from inspiring English sources
Just as importantly, King's research has given geneticists insights into the nature of cancer-causing genetic mutations in general.
Mutations in general are far more likely to be harmful than helpful, and the large, helpful ones were low-hanging fruit that were picked long ago in our evolutionary history and entrenched in the species.
To identify potentially pleiotropic morphogenesis genes, the screen included analysis of marked clones of homozygous mutant tracheal cells in heterozygous animals, plus a secondary screen to exclude mutations in general "house-keeping" genes.
However, we found that class 1 mutations, in general, have a more deleterious effect on pVHL affinity than class 2 mutations when analyzed via pull-down experiments using in vitro transcribed and translated (IVTT) pVHL under both stringent and mild buffer conditions (Fig. 4b and Supplementary Figure 4).
By targeting nonsense mutations in general, the PTC drug one day might help legions of patients across an expanding array of rare genetic ailments.
Thus, splice site mutations relatively often lead to the milder phenotypes when compared to ATP7A mutations in general.
Finally, as discussed in the previous section, rearrangement mutations are nonrandom, and point mutations and rearrangement mutations are in general related.
First, Krauthammer et al. 47 reported that somatic activating Rac1 mutations, ranking third after BRAF- and NRAS-mutations, in general, occur significantly more often in men than in women.
The process ensured that the chromosome z in the β/z male was devoid of recessive lethal mutation in general, but newly arisen recessive lethal mutation in F3 may escape such surveillance.
Although TP53 mutation in general was associated with aggressive tumour/patient characteristics, missense mutations outside any conserved or structural domain did not affect the clinical outcome (risk of disseminated disease and death).
Solvent-exposed mutations would in general be expected to be less destabilizing than buried mutations at interfaces or within the protein core.
