Sentence examples for mutations in further from inspiring English sources
Screenings for mutations in further genes are specified in Table 1.
Therefore, we grouped together patients with any HFE mutation in further analyses, in order to better characterize the effect of TMPRSS6 genotype.
Stepwise accumulation of mutations was observed in two patients with N155H followed by the secondary E92Q, V151I and/or G163R mutations resulting in further increase raltegravir and elvitegravir resistance and often enhanced replicative capacity [ 27, 65].
Moreover, the identification of mutations in PIK3R1 further emphasizes the importance of the PI3-kinase pathway in UC.
The ZF1 mutant (KLF6-Z1A5), doubled KLF6 half-life to ∼40 min. Additional mutations in ZF2 (KLfurtherZ2A6) further significantly increased the half-life (Figure 6).
Hence, we chose to investigate subclonal IgV mutations in all further experiments.
Mutations in three further membrane proteins (the Na+/K+ ATPase, the Ca2+ ATPase and Cav1.3) have been described.
We subsequently added mutations in two further patients with TUBA1A mutations found by clinical testing (p.M377V and p.R390C), but did not include them in our cohort analysis.
As the majority of cancer cells have mutations in p53, further studies on the relationship between p53 and HGFIN expression, and its role in tumor genesis and bone invasion, might uncover novel therapy targets for breast and other cancers.
Importantly, a broad range of epigenetic modifiers are frequently inactivated by somatic mutations in UC, further highlighting the role of epigenetic perturbations in UC development and disease progression [ 12- 14].
Sanger sequencing of the CACNA1B exons coding for the protein portion spanning from III-S5 to III-S6 failed to reveal other mutations in a further 47 M-D cases.
