Sentence examples for mutations in developmental from inspiring English sources

Dominant mutations in developmental MyHC isoform genes (MYH3 and MYH8) are associated with distal arthrogryposis syndromes.

Mutations in developmental regulatory genes are related to dental development defects.

In addition, the findings indicate that genetic predisposition to type 2 diabetes may arise from mutations in developmental genes, which may not necessarily result in an early postnatal phenotype but manifest later in life.

Nevertheless, this observation should be taken cautiously as mutations in developmental genes could cause lethality and also because gene expression data, mostly obtained from rodent species, might not be completely valid for humans.

Recent large scale studies have particularly demonstrated its efficacy for the identification of de novo mutations in developmental disorders that were hitherto intractable using standard genetic investigations (Wright et al., 2015).

However, the identification of MEK1 and MEK2 mutations in developmental syndromes as well as chemotherapy-resistant tumors, and the discovery of genomic variants in MEK1 and MEK2 have led to the realization the extent of genomic variation associated with MEKs is much greater than had been appreciated.

An extensive inter-pair interface, conserved for the first-to-second and third-to-fourth PE interactions, contributes to a compact platform-like architecture, which is disrupted by mutations implicated in developmental diseases.

Some results support the idea that morphological evolution can occur basically by a small proportion of major effect mutations in structural, developmental or regulatory key genes (major gene effect hypothesis [2], [3].

Current evidence suggests that mutations in key developmental genes that control morphogenesis can cause morphological discontinuities with variable levels of fitness, and that the selective advantage of such variation is primarily filtered by the ecological context.

This lack of mechanistic breadth limits the range of biological systems that can be pharmacologically controlled, particularly with respect to disease states caused by mutations in specific developmental pathway components.

In this study, we describe the identification of the causative mutations in three developmental mutants via a strategy involving whole-genome sequencing of pooled DNA from 40 single spore isolates per strain of three mutants and the wild type, in addition to subsequent bioinformatics analyses.