Sentence examples for mutations in complex from inspiring English sources

The coding regions may, however, also be a good source of rare mutations in complex diseases, such as migraine.

Recently, haplogroup association studies have been used to define the role of mtDNA mutations in complex diseases and longevity.

Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed to both genetic and environmental factors.

Mutations in complex II are relatively rare, as are documented causes of mitochondrial disorders in general.

Therefore, it is the mutations in complex I components that cause the suppression of the mod1 phenotypes.

In the two cells with isolated complex I defects we detected two homoplasmic mutations in complex I genes.

Associations with complex I mtDNA SNPs such as ND4 T12027C and ND5 C12403T have been reported in schizophrenia [59], [60] and ND1 T3644C mutation in complex I in BD [52].

In cells with a mutation in complex IV causing ∼40% residual complex IV activity, the mitochondrial membrane potential was not significantly different from controls.

We have found that a severe mutation in complex I changes the mechanism of maintenance of mitochondrial membrane potential in neurons and astrocytes.

The B2-CCL16 cells die in galactose in the absence of metformin or phenformin since they harbor a mutation in complex I. Taken together, these results confirm that the anti-proliferative effects of metformin and phenformin require mitochondrial complex I inhibition.

Despite the higher rate of reactive oxygen species production that we have measured in CY2-I neurons, the mutation in complex IV was not associated with a significant change in glutathione concentration in the neurons or astrocytes (Fig. 5).