Sentence examples for mutations in colon from inspiring English sources

K-ras mutations are more common in colon cancer than in rectal cancer, the number of mutations in colon tumours is higher than in rectal tumours, and the mutational pattern restricted to the APC gene is more frequent in rectal than colon cancer [ 28].

One team used it to detect drug resistance mutations in colon tumors and then devised a drug combination to beat the cancer back.

The majority of somatic APC mutations in colon cancers result in overexpression of a truncated protein that includes all of the M2-APC region and part of M3-APC (Table 1).

Oba et al. screened for EPHB2 mutations in colon tumors and respective normal colon tissues from 50 patients with colorectal cancer, and identified an intron 8 alteration in a single tumor sample, which results in a nonsense mutation.

Three signalling pathway signatures were developed to characterise specific types of oncogenic mutations in colon cancer (KRAS, BRAF or PIK3CA).

The most common mutations in colon cancer and derived cell lines result in truncating mutations of the APC protein.

The CpG island methylator phenotype (CIMP) is a distinct phenotype associated with microsatellite instability (MSI) and BRAF mutation in colon cancer.

These three mutations have been previously described as follows: c.1942G>T, a somatic mutation in colon cancer (Cancer Genome Atlas Network, 2012); c.1465insC, a germline mutation in diffuse gastric cancer (Barber et al, 2008); and c.2398delC, a founder mutation in four Newfoundland families with diffuse gastric and ILC (Kaurah et al, 2007).

Interestingly, when stage II colon and rectal tumours were analysed separately, only the presence of a KRAS mutation in colon cancers was associated with a trend towards a worse DFS (HR, 3.64; P=0.07), and these results were maintained in the Cox regression analysis (HR, 4.163; P=0.07).

Such genome-wide screens for transcripts harbouring truncating mutations has proved successful in identifying sporadic nonsense mutations involved in colon cancer [ 18, 19, 23, 24], prostate cancer [ 25, 26], melanoma [ 27], mantle cell lymphoma [ 28] and clear cell renal cell carcinoma [ 29].

Your articles about advances in gene sequencing tools note that there are no drugs yet to target the mutations found in colon and several other cancers.