The accumulation of mutations in certain cancers may reflect a mutator phenotype with globally random mutations [4] [6].
Although both the two- and five-factor models predict the general shape of the mutational pattern, both also fail to account for the high density of mutations in certain bins, particularly 7, 20, and 25.
Scientists have found that mutations in certain genes can increase the risk of developing hernias.
These were then grown in culture (pictured) and sequenced to reveal key mutations in certain cancer genes.
To identify causal mutations in certain genes in children with acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP).
It is known that rare human mutations in certain genes in bile acid and bile metabolic pathway influence blood cholesterol levels.
Subtypes of autism seem to be associated with mutations in certain genes, which may begin to explain such long-standing mysteries as why some cases of autism produce severe symptoms while others cause more modest behavioral tics.
In other words, mutations in certain genes appear to drive melanoma development.
They attribute this to the vagaries of natural selection, which may at times constrain specific genetic mutations in certain lineages.
They have identified about 10 of these types of Parkinson's, each caused, they believe, by mutations in certain genes.
Further, several new targeted therapies are currently in development and show great promise at reversing phenotypes caused by activating mutations in certain genes (e.g. IDH1, EZH2).
