Sentence examples for mutations in aging from inspiring English sources

To test the causative role of mtDNA mutations in aging we have developed the mtDNA mutator mouse that accumulates high levels of point mutations due to a proofreading deficiency of the mitochondrial DNA polymerase (POLG) [ 12].

Development of the mtDNA mutator mouse, an animal with mutated mtDNA polymerase γ, highlighted the strong potential for mtDNA mutations in aging.

All tissues from adult subjects show the presence of mitochondrial DNA molecules with deletions [24], and the accumulation of mtDNA mutations in aging contributes significantly to the decline of mitochondrial energy production that characterizes the aging process in many tissues [25] [26].

It was therefore long assumed that ROS was the major source of somatic (acquired) mtDNA mutations in aging [22,23].

This notion again argues against the importance of ROS in driving the accumulation of mtDNA mutations in aging.

To explore the potential role of mtDNA point mutations in aging, it is therefore necessary to use animal models.

An important goal in ageing research is to determine the incidence of mtDNA point mutations in ageing human tissues.

It remains to be seen whether differentiation-inducing checkpoints contribute to the prevention of the accumulation of mutations in ageing stem cells and cancer initiation.

Other stress-inducible mutation mechanisms that also require RpoS include transposition/excision of phage Mu 75, 76, stress-inducible point mutation 77, and transposition 78 in Pseudomonas putida, DSB-independent stress-induced mutation in aging colonies of an E. coli natural isolate 79, and DSB-dependent 12, 33 stress-induced gene amplification in E. coli 28.

Similar to p16Ink4a, p53, is also a widely recognized tumor suppressor, where loss of function mutations are associated with tumorigenesis and gain of function mutations result in aging and senescence [59].

Clonal expansion of mtDNA mutations occurs in aging post-mitotic tissues.