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One is to create numerous mutations in a single gene.
"Big-benefit mutations in a bacteriophage inhibited with heat".
We found that mutations in a gene called daf-2 doubled life span.
The defect results from one of many possible mutations in a very large gene.
Directed evolution works by making numerous mutations in a gene that produces a particular protein.
The condition, MCAD deficiency, is caused by mutations in a gene involved in fat metabolism.
Diversa and Applied Molecular Evolution tend to use mutations in a single gene.
Some of the earliest work has until now been with inherited diseases caused by mutations in a single gene.
Women with mutations in a gene called Brca1 tend to develop this kind of aggressive breast tumor.
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Mutations in A-type lamins cause a wide range of human genetic disorders (laminopathies).
Mutations in A-type lamins lead to disease in humans.
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