Both theoretical models (7) and cell culture models (3) have produced data to suggest that mutations imparting a high propensity to aggregate are disproportionately associated with disease of shorter duration.
Taken together, the data indicate that the FLL mutation imparts a gain-of-function on FIT2 resulting in increased lipid droplet accumulation.
In a Sup− cell, the amber mutation imparts a premature translational stop resulting in a truncated 68 a.a. non-functional gpD fragment that is incapable of stabilizing and packaging full-length λ DNA.
For any somatic mutation imparting a clonal advantage to a stem/progenitor cell and leading to the generation of a steadily expanding clone, one would expect such a clone to be detectable at a smaller size at earlier and a larger size at later time points, as is the case for DNMT3A R882 and JAK2 V617 mutations.
Thus, in these samples there is either a loss of KRAS mutations or an accumulation of PIK3CA mutations, suggesting that PIK3CA mutations may impart a selective advantage in the lymph node.
Rapidly progressive sarcomas may acquire an array of genetic mutations that impart a particularly aggressive phenotype capable of out-pacing an immune response in an immunocompetent animal.
Daniel Stroock, a mathematics professor at Massachusetts Institute of Technology in Cambridge who has collaborated with Varadhan, says Varadhan's research has been a blessing to scientists in various disciplines: For instance, evolutionary biologists could rely on his work to calculate the chance that a specific mutation might impart a selective advantage to a species.
In the present study, we developed an EMS induced rice mutant, 'HTM-N22', exhibiting tolerance to a broad spectrum herbicide, 'Imazethapyr', and identified the mutations imparting tolerance to the herbicide.
We interpret this as indicating that the three types of clone acquired mutations imparting swa resistance after distinctly different periods of propagation, perhaps due to different stabilities of the cognate PrPSc.
Although cell-free protein synthesis yielded an inferior TrEGI enzyme, we proceeded to use cell-free expression as a tool to rapidly screen mutants of TrEGI, with the assumption that the effect of mutations imparting thermostability will be conserved upon expression in fungal hosts such as T. reesei.
