Sentence examples for mutations impact the from inspiring English sources

More studies are required to understand how these non-neutral mutations impact the biological network.

Meanwhile, presenilin mutations impact the cleavage of numerous proteins also with synaptic functions.

Future work further clarifying how TRPM8 mutations impact the channel may provide better clues to which direction pharmacological approaches should take, activating or blocking channel function.

Because MeCP2 is present at high concentrations in neuronal tissues and the full-length protein is reported to cooperatively bind DNA in chromatin as a dimer, it is possible that some of the structurally or thermodynamically unannotated Rett syndrome-linked mutations impact the dimer interface.

Memory deficits have been found in several lines of mice with mutations impacting the generation of robust circadian rhythms in behavior [8], [21] [26].

Moreover, the two contributory de novo mutations in this patient support the prior observation that up to 5% of patients with identified diagnoses can have two de novo mutations impacting the disease phenotype.

Six features were selected to build a classifier: the reference allele, the substituted allele, the mutation type, the mutation impact, the subcellular location and the protein domain.

Indeed all mutations impact on the internal coordination of the HuPrP(125 228) α-fold and the type and magnitude of the effect depend on the intrinsic features of the mutation, as its identity and its positioning along the sequence [Figure 3].

In order to comprehensively extract mutation impacts, the detection of several named entities and their relations, in particular mutations and protein properties, is required.

To estimate the likelihood that a mutation impacted the protein functionally, predictions were made based on PROVEAN (Choi et al. 2012).

Future studies will focus on determining how the Tp53 R270H mutation impacts the effectiveness of agents frequently used to treat patients with CaP, particularly androgen ablation and radiation therapy.