Sentence examples for mutations however the from inspiring English sources

Background Multiple congenital melanocytic naevi (CMN) in one individual are caused by somatic mosaicism for NRAS mutations; however, the lineage of the mutated cells remains uncertain.

LNA-PCR sequencing confirmed all 51 PIK3CA mutations; however, the mutation detection rate by standard Sanger sequencing was only 69% (35 of 51).

For selectively neutral mutations, however, the probability of fixation (u) is equal to 1/ 2N), because "any one of the 2N genes in the population is as likely as any other to be fixed, and so the probability that the new mutant will be the lucky one is 1/ 2N)" (Kimura 1979, p. 108).

Mutations in the β-cardiac myosin comprise ~40% of genetic mutations associated with HCM, and the converter domain of myosin is a hotspot for HCM-causing mutations; however, the underlying primary effects of these mutations on myosin's biomechanical function remain elusive.

Furthermore, multiple preclinical studies have focused on identifying synthetic lethal interactions with KRAS mutations; however, the majority of these synthetic lethal interactions have not been reproducible [55].

In the presence of compensatory mutations, however, the competitive interference between wild-type and resistant strains is more complex.

Exon 18 mutations are extremely rare comprising of 4.1% of all EGFR mutations and the delE709_T710insD mutation accounts for only 0.16% of mutations when occurring as a sole mutation, however, the frequency can vary with the kit utilized for testing.

In addition, bypass efficiency is significantly lower both for the I38A mutation of the roof-aa and for the adjacent A39T mutation; however, the I38A/A39T double mutant is almost as active as wild-type UmuC V), which probably reflects the following.

In familial cases of breast cancer lacking a BRCA1/ BRCA2 mutation, however, the frequency of the hCHK2 1100delC mutation was significantly elevated, at 5.1% (P = 0.00000003).

Interestingly, the rhesus monkey Ugt1a7 in the whole-genome-shotgun traces has no stop codon mutation; however, the Ugt1a7 in the finished BAC clone (Accession No. AC171066.4) has a stop codon at coding position 670.

Microdissection of the surrounding Barrett's epithelium revealed a p53non-sensenon-senseutation; however, the underlying squamous island and contiguous oesophageal gland squamous duct were p53 wild-type, indicating the presence of a different clone to the surrounding Barrett's dysplasia.