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The creation of mtDNA mutator mice provided the first evidence that somatic mtDNA mutations have the capacity to cause a variety of aging phenotypes in mammals, and they do so without inducing ROS production or increasing oxidative stress.
In the same way that mass production moved the locus of industry from small shops to huge factories, today's mutations have the potential to shift us away from business models based on economies of scale, asset intensification, concentration and central control.
While NA mutations tend to make IFV resistant to one NAI drug, HA mutations have the potential to confer resistance to all NAI drugs.
Females who are heterozygous for X-linked Bcor mutations have the rare Oculofaciocardiodental (OFCD) syndrome, the primary subtype of OMIM #300166 microphthalmia, syndromic 2 (MCOPS2) [18].
In this sense our results shed some light into the rationality for vaccine design as the fact that some mutations have the potential to accumulate in time means that vaccines targeting epitopes containing them will eventually reduce their effectiveness.
Interestingly, in the wing there is a strong genetic interaction of ck/MyoVIIA with the fz-dsh-Drok-sqh-zip pathway, where ck/MyoVIIA mutations have the opposite effect of zip/MyoII heavy chain mutations [26] (Fig. 5A).
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Across microcosms, ecologically equivalent specialists arise by different mutations having the same or similar physiological impact.
Patients with class I mutations had the highest incidence of CFRD, and those with class V mutations had the lowest incidence (Fig. 2).
The patients with SLC2A1 mutations had the broadest spectrum of clinical phenotypes.
However, GISTs with these mutations had the same prognosis after curative surgery and under imatinib.
In particular, men with an MSH2 mutation have the highest risk for several types of cancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com