Sentence examples for mutations have specific from inspiring English sources

Thus, these two closely positioned point mutations have specific signatures for inhibitor sensitivity.

Studies vary in the extent to which they include women from ethnic backgrounds characterised by the presence of founder mutations, which will have specific population frequencies not applicable to a wider outbred population.

46 Although most COL7A1 mutations have been specific to individual families, some recurrent mutations have been reported in different patients.

Although mutations in ARID1B can cause CSS, both our data and the literature seem to indicate that not all patients with ARID1B mutations have the specific characteristics of CSS.

Patients with lung adenocarcinoma have specific mutations in the EGFR gene which lead to the activation of growth factor signaling and conferring susceptibility to tyrosine kinase inhibitors.

In vitro studies have determined several common mutations of Tp53 that have specific gain-of-function properties in addition to loss of function, including the ability to promote castration-resistant (CR) growth of CaP cells in some contexts.

These Alphs have specific mutations in the second conserved motif, GDXVDRG, in particular, the substitution of the second Asp for a neutral residue and substitution of the Arg for Lys [ 89].

We also discuss scenarios in which personalized drug repositioning could be particularly rewarding, such as for diseases that are rare or have specific mutations, as well as current challenges in this field.

Bone and soft tissue sarcomas can have specific gene mutations and express mutated proteins [ 100].

Tobacco and sun exposure are well-known mutagen sources that cause DNA damage and have specific mutation patterns.

The presence of two of the extremely rare E547K PIK3CA mutations in our cohort may have specific relevance in MBCs.