Your English writing platform
Discover LudwigSuggestions(1)
Exact(4)
All of these mutations have relatively high levels of VKOR activity in the presence of warfarin.
Deleterious mutations have relatively little effect on the evolution of genetic instability unless selection for additional driver mutations is very weak or if deleterious mutations are very common.
In other ancestral reconstruction studies, function-enhancing mutations have relatively minor effects, all less than a 50-fold gain in kcat/KM (Zhang and Rosenberg, 2002; Voordeckers et al., 2012; Risso et al., 2013).
DOI: http://dx.doi.org/10.7554/eLife.04279.006 10.7554/eLiFigure79.007 Figure 3 figure supplement 1. Mutations have relatively small fitness effects during growth on succinate compared to the benefits of threefold or more on DCM.
Similar(56)
His work also demonstrated that most mutations had relatively small effects, such as a change in eye color, and that rather than creating a new species in a single step, mutations served to increase variation within the existing population.
Although subsequent studies, using sequential short deletion mutants between E13 and T21 of p6gag, as well as a long fragment deletion mutant (S14 I31 of p6gag), suggested that these mutations had relatively tolerable effects on Gag processing and in vitro viral infectivity, the influences of deletion between P30 Y36 of p6gag, as observed in CRF07_BC in Taiwan, were not addressed.
Because a strain carrying an anonymous TS mutation has relatively little value in an era when genome sequencing has largely replaced genetic mapping, we have endeavored to identify mutations underlying several anonymous TS lethal mutations in Neurospora.
Alternatively, selection can act on standing genetic variation (that is, the beneficial mutation has relatively high frequency) leading to soft sweeps or even maintain variability [ 11- 13].
The capacity of the screen to detect mutations that each have relatively small effects demonstrates its remarkable power to identify pathways that function in a partially redundant fashion.
Although useful, a main limitation of methods based solely on mutation frequency is the inherent assumption that driver genes have relatively high mutation rates.
Single-stranded RNA viruses (which have relatively high mutation rate about of around one mutation per 3000 10,000 nucleotides (often expressed as the number of mutations per replication [ 17]) and this limits RNA viruses to relatively shorter lengths.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com