From a clinical standpoint, the discovery of these mutations has potential implications for patient management.
Given that mutations in KRAS and BRAF are mutually exclusive, BRAF mutations may have potential confounding effect when estimating the prognostic value of KRAS mutations.
This suggests that the combination of HER2 and PI3K therapies up front, if tolerable, might provide optimal treatment for patients with PIK3CA mutations and also have potential benefits for patients with PIK3CA wild-type tumors.
19– 21 Therefore, new agents capable of overcoming drug resistance conferred by primary or secondary activation loop mutations in KIT have potential therapeutic utility in drug-resistant GISTs, SM, AML, and other tumors.
These findings provide important understanding of the biology of these mutations, have the potential to be useful clinically and will likely pave the way for future studies that further investigate neuroanatomical correlations with clinical and pathological features.
In the same way that mass production moved the locus of industry from small shops to huge factories, today's mutations have the potential to shift us away from business models based on economies of scale, asset intensification, concentration and central control.
Additional studies have suggested that MEFV rare missense causative mutations have a potential modifying effect in IBD patients [27] [30].
While NA mutations tend to make IFV resistant to one NAI drug, HA mutations have the potential to confer resistance to all NAI drugs.
In this sense our results shed some light into the rationality for vaccine design as the fact that some mutations have the potential to accumulate in time means that vaccines targeting epitopes containing them will eventually reduce their effectiveness.
Although other factors likely influence progression, this study demonstrates that a process likely to be stochastic namely the acquisition of discrete genetic mutations drives progression of cervical dysplasias to invasive lethal carcinomas and that these mutations have the potential to serve as useful prognosticators.
