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Although p53 is the most frequently mutated gene in human cancers, p53 mutations have not been detected in primary neuroblastoma[39].
Many such mutations have not yet been identified, and even when a known mutation is found in a tumour, drugs to block its effects may be unavailable.
Furthermore, these mutations have not significantly changed the specific activities of firefly luciferases.
Moreover, oncogenic driver mutations have not been described for up to 30% of all melanomas.
However, drugs to counteract the effect of genetic mutations have not yet been found.
Naturally occurring and disease-causing activating mutations have not been identified in AT1 receptor.
These mutations have not been reported previously in the BIC or LOVD databases.
However, these mutations have not been identified in the more common types of migraine with typical aura.
However, the characteristics of PPGL with some types of gene mutations have not been fully elucidated due to their rarity.
On the other hand, Nav1.7 mutations that are associated with DS (nine mutations) and FEB (six mutations) have not been well characterized.
Although the population prevalence and mutation spectrum of β-thalassemia in most areas of south China have been characterized, the mutations have not been elucidated in Guizhou Province.
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