Sentence examples for mutations have negative from inspiring English sources

In 2009, Dr. Wendy Rubinstein and colleagues reported that almost half of Ashkenazi Jews identified with BRCA1/2 cancer-risk mutations have negative family histories for cancer.

11, 18 This study did demonstrate that the presence of BRAF and NRAS mutations had negative impact on DFS in this group of patients.

These analytical results demonstrated that the three single mutations had negative effects on the thermostability of AEXynM as predicted by total energy value calculation, among which one single mutation of C5T caused the most significant decrease in thermostability.

Though the lpa rice lines developed through mutation have negative impacts on plant performance, studies on barley and soybean emphasize the possibility of developing suitable rice lpa mutants when more attention is given simultaneously to yield, yield-related traits and agronomic performance.

But "now that it's known that this mutation has negative consequences, you may find that growers begin selecting for fruit that is uniformly darker green, rather than uniformly lighter green". Harry Klee, a specialist in the chemistry of fruit flavor at the University of Florida who was not involved in the study, said the work was a good step toward a better understanding of tomato flavor.

Therefore we conclude that Hira mutation has negative effects on sperm quantity.

Moreover, the majority of mutations have no negative impact on stereoselectivity.

First, eclipse length is longer in the mutants than in the ancestor at both temperatures, and therefore these mutations have a negative impact on this component of fitness.

We have previously shown that certain CDH1 mutations have a negative influence on survival of gastric carcinoma patients [ 33] and that CDH1 mutations are associated with enhanced EGFR activation [ 34, 35].

Although there is controversy concerning the most suitable method for determining p53 status, many studies revealed that the TP53 gene and associated protein mutations have a negative prognostic impact for overall survival [ 11- 13].

We suspect that mutations in this loop may have negative effects on overall stability.