Sentence examples for mutations have much from inspiring English sources

(E ) SGTx1 residues colored by ΔΔGo − ΔΔGp values to highlight positions where mutations have much larger effects on apparent affinity compared to membrane partitioning.

Amino acid differences with multiple base pair mutations have much lower (>2-fold) amino acid substitution probabilities (e.g. BLOSUM62 scores) when compared with those with single base pair mutations.

In a recent study, Russo and colleagues' results indicated that women with a family history of breast cancer or with BRCA1 mutations have much less pronounced changes related to pregnancy, suggesting that the BRCA1 gene may have a functional role in the branching pattern of the breast during lobular development [ 46].

However, we confirmed that patients with IDH1/2 mutations had much longer OS than those with no mutation).

Surprisingly, the Ghrhr lit / lit mutation had much larger effects on gene expression than the GHR-KO mutation, even though both mutations affect the same endocrine pathway.

Some mutations, though, have much higher frequencies than others, for example, p.Gly2019Ser and mutations altering codon Arg1441.

For unlinked sites, nonsynonymous mutations would have much shorter lifetimes to fixation than synonymous changes, given their substantial level of (positive or negative) selection inferred below.

It is now abundantly clear that pathogenic OPA1 mutations can have much more severe multisystemic consequences that are detrimental not only to optic nerve function, but also target other tissues that are frequently involved in other well-established mitochondrial syndromes (Amati-Bonneau et al., 2008; Hudson et al., 2008).

The M289A probe residue mutation did not have much effect on the first nick which appeared rapidly at the start of the reaction (Figure 4A, E).

Finally, others have expressed IP3R with mutations in sites that are phosphorylated by PKA and shown that the Po of the PM cation channels activated by adenophostin A is increased by forskolin (to activate PKA) for wild-type IP3R; IP3R with phospho-mimetic mutations are hyperactive, and those with mutations that prevent phosphorylation have much reduced activity (141).

On the other hand, results of this analysis suggest that dwarf mutations have a much larger and more consistent effect on IGF-I expression than CR treatments (as well as potential CR mimetic compounds).