Sentence examples for mutations have made from inspiring English sources

"We always thought 'cure.' " But the size of the gene and the variety of mutations have made even diagnosis problematic and researchers are now looking elsewhere for an answer.

Although discoveries such as KRAS gene mutations have made inroads into this field, we have not yet realized the full potential of targeted therapies.

Currently, 1p/19q chromosomal co-deletion, MGMT methylation, and IDH mutations have made their way into clinical practice, and a growing number of other markers are under investigation.

However, the long breeding cycles, high heterozygosities, lack of various degrees of preciseness in hybridization, and low frequencies of desirable mutations have made new varietal development highly resource-demanding.

Nevertheless, cryopreservation of tissues from each mutant line allows retrospective screens to be carried out for mutations in a gene of interest; advances in the rapid detection of mutations have made it practical to use this gene-driven approach (27, 28).

In this study, although the difference amount of repeat elements itself was insufficient to explain the two-fold difference in genome size between D. holocanthus and smooth pufferfish, this might be due to that mutations have made many ancient transposable elements unrecognizable.

Additionally, the rarity of the disorder, coupled with variable penetrance and phenotype even in individuals with similar mutations, has made it difficult to assess the impact of genetic lesions in SALL1 on cognitive or behavioral function in humans.

The wide distribution of the oncogenic mutations has made it unclear as to the mechanism of up-regulation of PI3K in cancers, however, some of the up-regulating mutations were shown to increase the affinity of the enzyme for lipid membranes (Mandelker et al., 2009; Burke et al., 2012; Hon et al., 2012).

In one, the mutation has made the white-skinned trait dominant; in the other, the mutation has made it recessive.

Indeed the uniparental inheritance of mtDNA, as well as the high rate of mutation, has made mtDNA invaluable in charting the evolution of man [30].

Shaping it via mutation has made it instead of binding the great majority of nonneutralizing antibodies to gp120, but bound the b12 and VRC01.