Exact(5)
We are especially interested in determining the roles that novel gene mutations have in the genesis of canine and feline meningioma and are utilizing RNAseq to better understand the transcriptome of this tumor.
On face value, such observations would again argue against NII being pathognomic for PGRN mutations, though in at least some cases included in the latter studies [ 3, 13] PGRN mutations have in fact now been found (Mackenzie, personal communication).
The similar effects that 5-HT3A subunit mutations have in homomeric and heteromeric receptors have shown that these homology models of A+A− binding sites are relevant to both receptor types (Thompson et al., 2011c).
Mutations have in the past taken the form of point, frame-shift, and translocation mutations, all of which involve swapping, switching, or shifting binary bits, in the case of binary-coded chromosomes.
However, to fully understand the role that signalling protein mutations have in oncogenesis, and to design treatments with minimal side effects, we need to elucidate the role that signalling pathways have in controlling cellular behaviour within normal, homeostatic tissues in situ.
Similar(55)
All isolates with mutations had in vitro resistance to antibiotics related with those genetic patterns.
Although spontaneous mutations have arisen in CD-1 mice, very few have been mapped.
A further five mutations have resulted in putative alloacceptor changes.
CHRNA4 mutations have been found in sporadic NFLE, but no mutation in CHRNB2 or CHRNA2 have been reported.
In recent years, a plethora of mutations have been discovered in chromatin modifier genes.
Several gene mutations have been identified in celiac disease.
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