Sentence examples for mutations have important from inspiring English sources

Among them, V600K mutations have important implications for determining eligibility for treatment with BRAF or MEK inhibitors.

The present data do not suggest that iron overload or the major HFE gene mutations have important pathophysiological consequences in community-based type 2 diabetic patients.

However, despite these discrepancies, the high frequency of PIK3CA mutation and the discovery of hotspot mutations have important clinical implications for diagnosis, prognosis and therapy.

The presence of transmitted resistance mutations has important implications for clinical management of HIV patients [ 26, 27].

Finally, the description and characterization of novel PRPS1 mutations has important consequences not only for diagnosis, but also for therapeutic and prevention purposes.

If the use of mitochondrial DNA and in particular somatic mitochondrial genome mutations has important utility and medical merit, much of the data requires critical follow-up from a pseudogene perspective.

Genetic factors, such as BRCA mutation, have important role in young women with IBCA (Robson et al, 1998; Greenblatt et al, 2001).

The identification of this MSH2 founder mutation has important implications for the design of mutation-detection strategies for the southern Chinese population.

The discovery of the C9ORF72 mutation has important treatment implications for patients with FTD.

Further, the mutation has important implications for the transmission and control of MDR-TB [ 17].

The Fiskerstrand et al. study [ 6], which identified the causative GUCY2C mutation, has important implications from mechanistic, diagnostic and therapeutic perspectives.