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Future studies are necessary to determine which mutations have functional consequences and whether any associated therapeutic vulnerabilities can be exploited.
Neither of these mutations have functional consequence.
Available x-ray data showing cytochrome bc1 inhibitors bound to both Qi and Q0 sites suggest that these mutations have functional consequences.
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We hope that our proposed approach can be used to discover mutations having functional impact.
We demonstrate that this mutation has functional consequences because the mutant molecules allow cells to proliferate at much higher levels and do not induce or prevent apoptosis.
We tested whether the Bst mutation has functional effects on the PLR – a readily quantifiable behavior driven by ipRGCs – and circadian rhythm.
The transformed scores are used to rank the somatic mutations that have functional effects, and mutations with higher transFIC scores are considered candidate cancer drivers.
Based on these criteria, tRNASer UCN) 7492 T > C mutations may have functional significance.
On the other hand, non-neutral mutations may have functional consequences that may be assessed by analyzing the conservation indices.
Synonymous mutations may have functional consequences because of selective constraints acting on certain codons (Chamary et al. 2006).
TEs have been proposed to increase evolvability by providing new genetic elements that are more likely than single mutations to have functional consequences.
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