Sentence examples for mutations have distinct from inspiring English sources

PS pathogenic mutations have distinct effects on the γ - and/or ε-secretase-dependent cleavages of different substrates including Notch, APP and N-Cadherin [39], [44], [52].

It is worth noting that the aoR3H and ioFL mutations have distinct effects on Kv3.3 function.

Neurological disorders associated with CACNA1A gene mutations have distinct clinical phenotypes.

In addition, the HX and UbdA mutations have distinct effects for the majority of interactions established by Ubx or AbdA.

See also Figure 6 figure supplement 2. Note that the HX and UbdA mutations have distinct or opposite effects for most of the interactions in Ubx and AbdA.

Furthermore, we demonstrate that different mutations have distinct effects on COL4A1 and COL4A2 biosynthesis and that these effects may be preventable under conditions that promote protein folding.

Whereas the expression of five DAF-16/FoxO target genes is induced in a DAF-16/FoxO-dependent manner in akt-1 null mutants, sgk-1 null) sgk-1 nullgf) mutandonsgk-1 gfstinct sgk-1 gfing influences on the expression of specific DAF-16/FoxO target genes.

We show that the mutation has distinct effects on these two types of neurons, supporting a cell-type specific role of Disc1 in establishing structural connections among neurons.

These results indicate that each mutation has distinct effects on downstream signaling that may be influenced by the cellular environment and/or modifying genes.

The divergent sensitivity to CRIS of HepG2 and HC-AFW1 cells suggests that different CTNNB1 mutations may have distinct effects on Gln metabolism in tumour cells.

Recent work in evolutionary and quantitative genetics has shown that mutations often have distinct effects in males and females, by differentially affecting male and female traits (e.g., Mackay 2001) or by having sex-specific fitness consequences (e.g., Rice and Chippindale 2001; Whitlock and Agrawal 2009; Innocenti et al. 2011).