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There is evidence indicating different PIK3CA mutations have differing effects on PIK3CA signaling and AKT phosphorylation, and therefore may determine prognosis.
Since previous reports have shown that PIK3CA mutations have differing effects on PIK3CA signaling and AKT phosphorylation, we investigated the role of different PIK3CA mutations in relation to ARID1A mutation or loss by IHC.
More importantly, these mutations have differing influences on the promiscuity of the mutant enzyme such that it can also accept other amino acid substrates.
Similar(57)
Our data provide clear evidence of this; both the R102K mutation and the loop insertion have differing kinetic effects when introduced in the modern vs ancestral proteins.
The interviewees have differing opinions.
Experts have differing opinions on the subject.
These data suggest that demographic histories or mutation probabilities have differed between species groups.
Studies have differed, though.
Their motivations may have differed.
Critics have differed sharply here.
Their answers have differed only in style.
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