Sentence examples for mutations have different from inspiring English sources

Also, an important fundamental question is why, in patients with systemic distribution of mutated mtDNA, clinical manifestations are usually organ-specific and different mutations have different clinical pictures.

30 The difference in outcomes between Del19 and L858R requires further research; however, preclinical studies suggest that Del19 and L858R mutations have different biological properties, with patterns of EGFR amplification and EGFR autophosphorylation differing between cell lines containing these mutations.

MECP2 mutations have different impacts in protein function depending on where the mutation lies.

This seems to be a possible explanation for the reported conflicting results published in the literature, since there could be more than one interpretation when two events (exon 9 and exon 20 mutations) have different and opposite effects.

Under the 'EVT' model [4], [5], changes that cause larger increases in fitness are assumed to have greater fitness, thus different de novo resistance-increasing mutations have different probabilities of fixation.

Polymorphic mutations have different effects on fitness.

Interestingly, and consistent with our steady-state observations, the A530V (Kd = 219 nM) and A530T (Kd = 513 nM) mutations had different effects on pVHL affinity, despite affecting the same residue.

Argentinean AIP patients with other mutations had different alleles for the markers [ 28].

However, the rpoB mutations had different fitness effects across three genetic backgrounds and six environments.

This conclusion agreed with our earlier data showing that the stc mutations had different effects on lifespan in different genetic backgrounds [ 5].

It is also possible that changes to Val510 may have multiple effects because we observed that various mutations had different effects in promoting maturation of Cys-less or Δ508-CFTR (see below).