Sentence examples for mutations have deleterious from inspiring English sources

In optimized populations, most mutations have deleterious effects, such that low mutation rates are favoured.

Given that known telomere maintenance genes are highly conserved [61] and mutations have deleterious consequences [23], most functional common variants (> 5%) will likely have small effects.

Therefore, the classification of mutations as deleterious depends greatly upon the genetic background into which that mutation is incorporated, and fewer mutations have deleterious effects in genetic backgrounds with poor fitness [44].

The situation changes when mutations have deleterious effects.

Multiple mutations have deleterious effects on functinal importance and breast cancer-related genes (Table  5, Additional file 1: Table S1).

Though we did not provide in vitro evidence that these mutations have deleterious consequences, it is likely that they cause GK haplo-insufficiency (11, 12).

Taken together, our results demonstrate that the presence of ico missense mutations has deleterious effects on cell proliferation or survival even in tissues where Drosophila EF-G1 is apparently not required.

The majority of mutations had deleterious effects on fitness, but there was evidence for a substantial fraction, up to 40%, being beneficial for some of the putative fitness traits.

When CGI harbors TSS and becomes a dominate regulator of gene transcription, the mutational forces that induce mutations might have deleterious impact.

We then integrate over all mutational effects to estimate f SDM, the fraction of mutations that have deleterious effects in the range given by s c, so that U SDM = U TOT * f SDM.

But mutations often have deleterious effects on functions that are essential for survival.