Among the mutations in PA domain 2 contact residues, the D152H mutation had almost no effect on the pH threshold of pore formation (data not shown).
In S. cerevisae mutations in the SPT3 gene have almost identical consequences to SPT8 mutations.
However, such high-cost mutations have never been very frequent among TDR HIV, and have almost vanished in the course of the recent treatment improvements.
Hovercraft have almost disappeared.
Currently, K27M and G34R/V mutations have been found almost exclusively in pediatric HGGs, including CNS-PNET (11%, G34R), though sporadic mutations at these residues have been recently noted in osteosarcoma (G34W) and MDS (K27N) (Attieh et al., 2013; Gessi et al., 2013; Joseph et al., 2013).
APC gene mutations have been described almost exclusively in colorectal cancer.
As PcG mutations have been described almost exclusively in haematological malignancies (Chase and Cross, 2011), there is currently no genetic evidence to predict their efficacy in solid tumours.
TET2 mutations have been reported in almost all coding regions including missense, nonsense, or frameshift mutations.
14, 57, 60 Mutations have been described in almost all exons (except exons 1 and 2).
Almost 2000 mutations have been described, but ∼70% of patients carry at least one F508del-CFTR mutation.
