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Attaining a high sensitivity for transmitted resistance is challenging because the large number of HIV-1 drug-resistance mutations has the potential to make the list unwieldy.
Identification of mismatch repair gene mutations has the potential to impact screening and treatment decisions in these women.
Given the high number of human transcripts carrying at least one uORF, the in-depth analysis of 5′ leader sequence mutations has the potential to substantially widen the spectrum of diseases with molecularly resolved etiology.
Between- and within-species variation in the rate and spectrum of mitochondrial genome mutations has the potential to confound evolutionary analyses where the mitochondrial mutation process is presumed to be constant (Baer et al. 2007).
Beerenwinkel et al. [ 132] related the waiting time to the population size, mutation rate, and the advantage of the driver mutations and showed that selective advantage of mutations has the largest effect on the evolutionary dynamics of tumorigenesis.
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Across microcosms, ecologically equivalent specialists arise by different mutations having the same or similar physiological impact.
Cases with other RET mutations have the most indolent course, and those with no RET mutations have an intermediate risk.
Patients with class I mutations had the highest incidence of CFRD, and those with class V mutations had the lowest incidence (Fig. 2).
We have assumed that all driver mutations have the same consequence for a cell's fitness.
The patients with SLC2A1 mutations had the broadest spectrum of clinical phenotypes.
While myosins are highly conserved, not all mutations have the same effect on all myosins.
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