Sentence examples for mutations has generally from inspiring English sources

However, biomedical research about somatic mutations has generally been limited to a few genes in a few cancer types.

In H. influenzae, gyrA is the primary target for fluoroquinolones because gyrA mutations have generally arisen before parC mutations in resistant clinical isolates (2 ).

The most pronounced longevity effects of single-gene mutations have generally been seen in C. elegans, in which the disruption of several dozen genes has been reported to prolong lifespan by 50-150% [ 2, 5].

In view of these observations in mouse models systems, together with the widespread occurrence of mutations that activate Wnt signaling in human cancers of other tissues, it is particularly surprising that equivalent mutations have generally not been detected in human breast cancers.

Increased frequency of p53 mutations has been generally observed in advanced stage CaP and metastatic prostate cancer cell lines.

Gene disruption in higher plants has generally depended on incidental mutations or random insertions of transgenes such as T-DNA and transposons.

Therefore, gene modification in higher plants has generally depended on the occurrence of incidental mutations or random insertions of designed T-DNA.

It has generally proved successful.

Romania has generally fertile soils.

Although fibrin too is an insoluble fibre, fibrinogen has generally not been considered as amyloidogenic, nor fibrin as an amyloid protein (although it can become so in the presence of a rare mutation in the fibrinogen a chain60,61,62,63).

He has generally been supportive.