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Notably, the partial suppression of HIV in treated individuals harboring viruses with drug-resistant mutations has also been linked to impaired viral fitness.
A high frequency of PIK3CA mutations has also been found in lobular carcinoma [ 16, 31].
Investigation of the host response to viruses possessing specific mutations has also been investigated.
A high frequency of Trp53 mutations has also been observed in human BRCA-linked tumors.
The association between sensitivity to AKT inhibition and specific PIK3CA mutations has also been observed in thyroid and breast cancer.
One of these mutations has also been found in one ALS patient, adding evidence for its pathogenic character.
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Additional HA mutations, with or without accompanying NA mutations, have also been reported in other studies [21], [25] [28].
Moreover, some of these and other mutations have also occurred repeatedly in puffer fish channels.
In addition, many post-twinning single nucleotide mutations have also been reported [42 45].
Danon disease is an X-linked dominant disorder, though spontaneous mutations have also been reported.
On the other hand, single gene mutations have also contributed much to plant and animal breeding.
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