Sentence examples for mutations had initially from inspiring English sources

The LMNA mutations had initially been identified among DCM patients who participated in the molecular genetics study of DCM carried out in collaboration between the Helsinki University Hospital and the University of Kuopio [4], [14].

This negative interaction is equivalent to robustness, and mutations will have initially small (or nearly neutral) effects.

10– 12 In this study, we used the same approach and ascertained mutations in a specific region of PLP1 that had initially not been identified.

This had initially puzzled me.

The ministry had initially declined to comment.

This had initially been regarded as background noise, but in retrospect is completely consistent with somatic mosaicism for the p.F556L NLRP3 mutation in this child with CINCA syndrome.

The mutations had apparently appeared spontaneously in each affected family.

19 mutations had not been described previously.

Pedigree studies have initially recognized two mutations in GATA2 in familial AML, p.T354M, and p.T355del, both in the second zinc finger (ZF-2) of GATA2 16– 18, while two other mutations; p.R308P and p.A350-N351ins8 associatedated with de novo AML 78.

The total number of mutations identified is continuously growing due to mutational analyses in different patient cohorts by competitive research groups once a gene has initially been found.

Relapses with loss of NPM1 mutation have been initially interpreted as secondary AML in the literature because the tumor cells gained independent genetic events, like MLL partial tandem duplications.