Sentence examples for mutations given a from inspiring English sources
Here we present a modified version of SIFT called Bi-directional SIFT (B-SIFT) which is able to identify both deleterious and a subset of activating mutations given a protein sequence and a query mutation within that sequence.
Jessica Queller's article about BRCA mutations gives a compelling look into the quandaries faced by women who are (or might be) carriers of these genetic predispositions to breast cancer.
With reversion of the CTL mutations in the recipient, apparently some of these compensatory mutations give a fitness cost themselves, driving their reversion.
All individuals tested for BRCA1/2 mutations gave a signed informed consent.
A number of mutations gave increased thermostability and a combination of six of these mutations gave a protein with an increase in Tm of 21 °C.
It is noteworthy that not all nd-HPFH mutations give a reproducible HPFH phenotype in transgenic mice (unpublished data).
The current distribution of 161 non-intronic mutations gave a frequency of 13 non-intronic mutations/100 residues.
It turns out that quite a wide range of landscapes satisfy the condition (at least trivially) under point mutation given a sufficiently low mutation rate, while the property appears to be difficult to satisfy under genetic recombination.
From a cohort of 3 000–6 000 children, we anticipate that 6 12 children will have the m.1555A > G mutation, given a mutation frequency of 1 in 526 (95% CI 1 in 357 to 1 in 770) [ 14].
In a recent study, Bozic et al. [ 130] provided an equation for the proportion of expected passenger mutations versus the proportion of the drivers and estimated that driver mutations give an average fitness advantage of 0.4%%.
The reconstruction involved 3,955 point mutations, giving an estimate of the overall per site r/m (the ratio of base substitutions introduced by recombination relative to point mutations) of 14.9; this compares with a typical range from around 0.1 to more than 30 for common pneumococcal lineages [ 36, 37].
