Sentence examples for mutations generates an from inspiring English sources

One family of such presynaptic proteins, whose deletion or loss-of-function mutations generates an epileptic phenotype in mouse and man, are the synapsins [11 13].

However, usually multiple mutational processes are operative in a single cancer sample, and combining their mutations generates a mixed composition of the patterns of somatic mutations.

Most importantly, we also found CHEK2 mutations generating a non-functional protein in our in vitro assays to be associated with drug resistance.

Because repetitions have been avoided, as described previously, each matching probe relates unambiguously to a single position in the target sequence (unless previously unseen mutations generate a sequence that is repeated elsewhere in the probe library [11]).

Nonsense mutations generate a premature stop codon and often a non-functional truncated protein product.

Such mutations generated a total of eleven AAS related to drug resistant.

Deletions, insertions and missense mutations generating a STOP codon were scored as high-impact mutations (score 3).

In toeprinting assays, these deletion mutations generated a pretranslocation toeprint at the same position as the WT RNA using the antibiotic edeine as an inhibitor in the lysate.

Five δ-sarcoglycan mutations generate a protein with a truncated extracellular domain and cause clinical phenotypes from LGMD to DMD-like in homozygous patients.

It is therefore not clear whether these mutations generate a misfolded protein intercepted by the ERAD-C machinery or whether they also abrogate unknown functions located therein.

Forty mutations are described in the γ-sarcoglycan gene (SGCG), 16 missense mutations generating a full protein with a single residue substitution (Fig. 5) and 24 that generate a truncated protein or no protein at all.