Sentence examples for mutations generated to from inspiring English sources

This is asked in part to address the observation that the mutations generated to 'destabilize' the apo-LapD-output domain did not make it constitutively active as predicted.

In the present study, two sets of homodimeric site-directed IgG1 mutations were generated to understand how individual Fc Met oxidation affects FcRn binding.

As with many drug development campaigns, resistance mutations were generated to guide identification of the drug target.

As a result, an excess number of mutations must be generated to insure adequate coverage.

Lipid A mutations have been generated to reduce immunogenicity, stimulating a much weaker immune response than wild-type strains.

60 Thus, mouse models with similar genetic mutations have been generated to provide phenotypic and mechanistic insights.

Several animal models of LMNA mutations have been generated to provide initial insights into the pathophysiology for LMNA-related DCM[ 16- 18].

In this study, we took advantages of TLR5 binding mutations generated form PAK [37] to delineate TLR5 mediated signaling pathways in cultured HCECs.

One possible explanation is that the inferred 'stamping machine' model of RNA segment replication in phage ϕ6 should lead to fewer mutations generated per infected cell, compared to a geometric mode of replication occurring in other RNA viruses [ 40].

Mice carrying a P250R mutation in FGFR1 were generated to mimic human PS.

The TP53 somatic mutations were aggregated, their spectrum was reported as specific for the given cancer type, and this spectrum was then compared to mutations generated experimentally in in vitro or in vivo systems [ 11,13].