Sentence examples for mutations generate a from inspiring English sources

Because repetitions have been avoided, as described previously, each matching probe relates unambiguously to a single position in the target sequence (unless previously unseen mutations generate a sequence that is repeated elsewhere in the probe library [11]).

Nonsense mutations generate a premature stop codon and often a non-functional truncated protein product.

Five δ-sarcoglycan mutations generate a protein with a truncated extracellular domain and cause clinical phenotypes from LGMD to DMD-like in homozygous patients.

It is therefore not clear whether these mutations generate a misfolded protein intercepted by the ERAD-C machinery or whether they also abrogate unknown functions located therein.

In Yersinia pestis, however, the BS2 site is not conserved and SL2 containing the other GcvB binding regions is followed by a uridine stretch; as expected, these mutations generate a truncated SroC homologue which is unable to regulate GcvB (Supplementary Fig S1D).

Interestingly, known mutations generate a novel amino-acid C terminus of the protein with loss of the KDEL motif and replacement of negatively with positively charged or neutral amino acids, whose proportion however varies according to the type of mutation and might underlie emerging differences in the clinical correlates and prognostic impact associated with the two types of mutations.

However, usually multiple mutational processes are operative in a single cancer sample, and combining their mutations generates a mixed composition of the patterns of somatic mutations.

Most importantly, we also found CHEK2 mutations generating a non-functional protein in our in vitro assays to be associated with drug resistance.

Such mutations generated a total of eleven AAS related to drug resistant.

Deletions, insertions and missense mutations generating a STOP codon were scored as high-impact mutations (score 3).

In toeprinting assays, these deletion mutations generated a pretranslocation toeprint at the same position as the WT RNA using the antibiotic edeine as an inhibitor in the lysate.