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A well-controlled lethal rate is fundamental for effective mutation and screening of the mutants.
Common recurrent changes, spanning genes potentially fundamental for ovarian carcinogenesis, regardless of BRCA mutations, and several candidate subtype-specific events were defined.
BRCA1 and BRCA2 are critical to prevent breast and ovarian cancers in mutation carriers but the proteins participate in processes that are fundamental for survival in other types of cells.
"Work is fundamental for dignity.
It was fundamental for me.
Moreover, substances are for Aristotle fundamental for predication as well as metaphysically fundamental.
"Education is fundamental for development.
Unidimensionality is fundamental for the Rasch Model.
Thus, VCP is fundamental for proteostasis.
Cyclin B1 is fundamental for cell proliferation.
These common events point to the involvement of genes fundamental for ovarian carcinogenesis, selected throughout the evolution of the tumours and providing advantage to any cancer cell, independently of the existence of germinal mutations in the BRCA1/2 genes.
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