Sentence examples for mutations from significant from inspiring English sources

The Mutational Significance in Cancer (MuSiC) uses sequence-based input to establish correlations among mutation sites, affected genes and pathways, and to discriminate abundant passenger mutations from significant mutation events.

Out of 327 patients found to harbour a pathogenic OPA1 mutation, 21 (6.4%) suffered from significant hearing impairment, a higher prevalence figure when compared with an age-matched normal population cohort.

Gene ontology analysis with Database for Annotation, Visualisation and Integrated Discovery using the data set of 856 genes with non-silent mutations from 22 patients showed significant enrichment of two classical CRC-related signalling pathways, namely ErbB signalling and cadherin/Wnt signalling (p<0.01, false discovery rate (FDR) <5%).

Quantification of the aggregation propensity, which is calculated from the ratio of insoluble to soluble forms of mutant SOD1 in cell lysates, of different mutations showed significant differences from WT SOD1 (Fig.  1B).

In order to identify potential driver mutations playing significant role in carcinogenesis, we compared sample mutations with known driver mutations with in-house software.

However, if wildtype p53 was transiently induced 8 days post-irradiation, circumventing the acute damage response and instead allowing mutations to develop, significant protection from radiation-associated lymphomas was noted as these mice survived 50% longer.

As a consequence, deciphering causative mutations from the sea of variants within an exome can be a significant challenge.

We did not find any significant differences between tumours originating from different mutation carriers or when comparing tumours from the carriers of mutations from the OCCR Ovarian Cancer Clusterregionon) (n = 7) and the end of the gene.

We show that this effect is largely due to sites with elevated mutation rates causing significant departures from the widely-used infinite sites mutation model.

The variable VAFs in different mutations from ctDNA implied variable clonality of different mutations.

As mosaicism would not normally be detected from mutation screening, a significant proportion of de novo cases in mosaic form can be missed.