Sentence examples for mutations from further from inspiring English sources

We exclude synonymous and nonsense non-synonymous mutations from further analysis, since the former causes no change in disorder score and the latter leads to truncation of the protein.

Therefore, we filtered out tumor tissues with ≥3 known potentially somatic mutations or with ≥2 back mutations from the further analyses.

DOI: http://dx.doi.org/10.7554/eLife.03553.003 When interrogating the mutations (99.8% of which occur at C G pairs; A T mutations were excluded from further analysis; all detected mutations are given in Supplementary file 1), the expected flanking sequence context of WR C was found for AID* and YC C for sA3G*.

To reduce the complexity of interpretation, cases with two mutations were excluded from further analysis.

2) The presentation of the model attempting to explain why TERT promoter mutations occur in certain tumor types, but not in others, could perhaps be more nuanced, and may be a little premature since additional TERT activating mutations may surface from further analysis in cancer that are currently thought to not fall in this category.

All of the PD patient brain tissue was sequenced for GBA1 mutations (the GBA1 pseudogene was taken into account) at Beckman Coulter Genomics (Danvers, MA) and any PD patient with a GBA1 mutation was removed from further analysis.

S11 is close to sterile, probably due to other mutations; we excluded it from further study.

The fact that even 3 5 additional coding region mutations (plus further mutations from the more variable control region) come in support of the respective haplogroup profile renders the haplogroup signature bullet-proof.

Additionally, mutation frequencies that were derived from less than three mutations, and mutations at poly-Q regions were excluded from further analysis to reduce noise levels.

However, the low frequency in piggyBac-mediated imprecise excision has hindered them from further creating mutations in the genes of interest directly.

This resource can be used to prioritize rare but recurrent mutations from human tumors for further study.