Recent advances in genome sequencing reveal common mutations in tumors from distinct tissue types.
Moreover, the results with inactivation-attenuating mutations to two residues from distinct parts of the channel (S631A: outer mouth of the channel pore; N588K: in the S5-Pore linker) provide evidence that IHERG inactivation does not play an obligatory role in doxepin's binding to the channel.
These artifact mutations are distinct from real CpG > TpG mutations, which dominate in most cancers.
This observation suggests that patients presenting with features of DC due to C16orf57 mutations are distinct from those due to mutations in the previously characterized DC genes.
In addition, high grade serous cancers without BRCA1 loss had low frequencies of positive p53 staining (4/12, 33%) and increased PIK3CA copy number (3/12, 25%), similar to cancers with BRCA1 mutations but distinct from cancers with epigenetic loss of BRCA1.
Similar to the previous analysis, Figure 2 includes different plot and sequence traces for MUTYH exon 13; First round: mutations clearly distinct from the wild type controls; but R426C heterozygote and G396C heterozygote have identical heteroduplex melting patterns (this differed in the subsequent sequencing).
With this set of genetic cell culture reagents, we have performed detailed, comparative phenotyping in order to determine the degree of overlap in abnormal cellular processes resulting from distinct NCL mutations.
Four amino acid substitutions resulting from distinct point mutations in the CSR gene prevent binding of various ALS-inhibiting herbicides and hence confer herbicide resistance.
10.7554/eLife.00966.007 Figure 2. CCO-deficient patches are clonal with distinct mutations from neighbouring patches.
This difference suggests that point mutations and rho− deletions in mtDNA result from distinct mechanisms.
