Sentence examples for mutations from constitutional from inspiring English sources

Therefore, the distinction of its driver mutations from constitutional variants is challenging.

Furthermore, four of the patients with hotspot mutations from whom constitutional DNA was tested harboured an additional deleterious germline mutation.

When a DNA variant was found, the corresponding blood DNA was sequenced in order to differentiate somatic events from constitutional variants (polymorphism or germline mutation).

To assess significance of mutations in our tumor dataset, we used a case control approach to compare the frequency of private mutations in each gene in the 60 tumor exomes to 543 control exomes, which were from constitutional DNA of patients with Mendelian diseases also sequenced at the McGill University and Genome Quebec Innovation Centre (Table S2).

To support somatic origin of the mutations, constitutional DNA from peripheral blood or non-tumourous tissue from the same patient was also analysed.

Recent evidence from microarray data argues that much of the malignant potential of neoplastic cells is a result of either somatic initiating mutations or constitutional polymorphisms present in normal tissue.

Stepping back from constitutional doctrine, what happened yesterday?

They may for example emanate from constitutional provisions.

DiGeorge Syndrome typically results from constitutional rearrangements at the 22q11 locus.

According to Rutter [ 10], this resistance is relative and results from constitutional and environmental factors.

The variable VAFs in different mutations from ctDNA implied variable clonality of different mutations.