Sentence examples for mutations for these from inspiring English sources

To do this, the software pulls in data from publicly available databases that list known mutations for these diseases – currently more than 8 million mutations – and looks for all of them, in each digital embryo.

Additionally, a second estrogen receptor distinct from the classical receptor has been identified, and loss-of-function mutations for these two receptor isoforms produce different skeletal phenotypes in mice.

Gross rearrangements within these two genes are frequently observed as the causative mutations for these diseases, and similar alterations within the large fragile sites that surround these genes are frequently observed in cancer cells.

The importance of the activating FcγRs (FcγRI, FcγRIII and FcγRIV in mice) and the inhibiting FcγRIIb in autoimmune diseases has been elucidated in mouse strains with targeted knockout mutations for these FcγRs [25], [26].

Probes that were more highly expressed in oocytes and embryos showed on the average a dn/ds approximately 15% smaller than probes being more highly expressed in the adult tissue in all the three species (p-values between 10e−20 and 10e−30) (Fig. 3d), indicating a stronger selection pressure against coding mutations for these genes.

Given that mutations for these receptors are available, they should be preferably employed.

For this reason, at this stage in the experiment it was decided to focus on these mutations for the creation of further mutant libraries.

Importantly, a functional role of these mutations for the process of colorectal carcinogenesis has to be investigated in further works in the future.

ClonalFrame also allowed us to estimate the relative rate of recombination over mutation for these five genes.

Because null mutations for both of these genes are viable, we can compare the loss of these AP2 subunits in a single organism for the first time.

This encouraged us to identify mutations for each of these three alleles using WGS.