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Assuming that available mutations for both Stam and Hrs correspond to null alleles, which is fully compatible with their molecular nature, it remains possible that these different roles on endosome maturation may be linked to distinct protein partners of Stam and Hrs.
Meanwhile, Chromosome 6 had less dense mutations for both genomes.
In two cases, mutations for both EGFR and KRAS were observed.
In these experiments, transgenic mice harboring heterozygous mutations for both FLT3/ITD and NPM1 rapidly developed an AML-like disease.
The frequencies of mutations for both the intention-to-treat and on-treatment populations are given in Supplementary Table 2.
The previously reported positional effect of mutations for both BRCA1 and BRCA2 is not borne out by our analysis.
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The usually fixed attachment angle of myosin to the actin filament is much less well defined with a random deviation of about 15° in the presence of the mutation for both apo and ADP states.
We analysed pretreatment tumour samples from five patients, including the only responder, for c-kit mutation for both genomic DNA and cDNAs.
Overall a co-dominance like-effect was observed for the L1014F mutation for both permethrin and DDT as the heterozygote individuals exhibited intermediate resistance levels contrary to the recessive effect originally described for this mutation (Martinez-Torres et al., 1998).
Further studies are warranted to investigate the functional impact of the mutation for both affected splice variants on the interaction of SH2B1 effector systems (e.g. leptin and insulin receptors), which play a major role in energy homeostasis.
Taken together, these results suggest that, although the rate of conversion of adducts into mutations may be different for lacZ and Pig-a, the kinetics of mutation accumulation for both mutation targets is the same once a mutation is fixed.
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