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Furthermore, we found that the ICR mutations exert different trans effects on AK029869 at different developmental times.
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PIK3CA mutations, which are located in exon 9 or exon 20, can coincide with KRAS and BRAF mutations [ 42] and exert different oncogenic effects including resistance to anti-EGFR therapies.
In conclusion, the present study suggests that various types of BAP1 mutations as well as WT BAP1 may exert different levels of growth suppression and/or DNA repair activities with different levels of residual functions.
Further, the genetic control of these processes is distinct as mutations in several DNA repair and HR genes exert different effects on T0, T1 and T2 [36], [49], [49].
Mutations found in the middle of the Aβ domain might exert different effects, (1) they might decrease the α-secretory cleavage of APP thereby facilitating amyloidogenic processing of APP [ 27], (2) these mutations could also increase the aggregation [ 28], (3) and/or alter the degradation by different proteases [ 29].
Mutations of classes I, II and III, are predicted by molecular modeling to exert different roles in the RHD of RPGR (supplementary material Table S1).
Various reproductive factors have been shown to exert different effects on the risk of breast cancer among BRCA1 and BRCA2 mutation carriers [ 15, 16].
However, different water injection modes exert different effects on mitigating water coning.
In turn, different GBH formulations have been shown to exert different effects on crops [20].
These results suggest that PC-1 might exert different functions on different cilia.
These genes (Rac2, Grap2 and Xpnpep3) exert different functions.
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