Sentence examples for mutations even when from inspiring English sources

The model also suggests that mutations, even when conservative, might all disturb the J-G/F interdomain interactions or destabilize the G/F domain, or both.

These data show that K a / K s can robustly detect drug resistance mutations even when the level of mixing equals or even exceeds 100%.

We excluded 1,215 mutations that were present in DAM as well as the SNP data, because public SNP resources may contain disease mutations even when "healthy" individuals are screened, especially when we consider DAMs for common, late-onset diseases.

Furthermore, we have demonstrated the effectiveness of the bovine SNP chip technology for whole-genome association analyses and elucidation of causative genetic mutations, even when relatively few samples are available.

A previous study by ourselves has shown that using spiked tumour DNA bearing a p53 mutation, the RSM method can detect such mutations even when present among a 10000-fold excess of nonmutated DNA (Jenkins et al, 2001a, 2001b).

Similarly, several studies have shown that most E. coli mutants from MPC plates had one or none of QRDR mutations even when parent strains with one gyrA mutation were used [ 5, 6, 11].

Second, congenic passenger segments aside, epistatic modifiers that happen to be closely linked to a sensitizing mutation, even when detected in other crosses, are impossible to detect in the 'cis' cross, because of transmission bias (e.g. Scn8a and Gabrg2 mutant mice are by definition all heterozygous for closely linked genes).

These experiments showed that most of the tested mappers gave correct results in mutation discovery even when used with their default settings.

When these conditions are met, BSA-seq can quickly identify mutations causing a mutant phenotype, even when the phenotypic effect of a mutation is very small.

LRRK2 remains the most frequently mutated gene, even when heterozygous PARK2 mutation carriers were included in the equation.

Further, eleven of the residues involved (including those harbouring the novel p.P318R, p.G323R and p.Y490N mutations) were invariant even when zebrafish was considered (Supp. Table S4).