Sentence examples for mutations especially for from inspiring English sources

It is possible, however, that older insertions are more difficult to tag by the high rate of mutations especially for TEs located to heterochromatic regions.

Despite the wide use of temperature-sensitive (ts) mutations, especially for studying essential genes that cause lethality when they are deleted, the molecular basis of ts phenotypes is largely unknown.

Our findings strongly indicate that inhibiting USP8 catalytic activity might be a promising therapeutic strategy for Cushing's disease cases with USP8 mutations, especially for patients with either residual or recurrent adenomas.

As seen for the majority of HCM causing mutations, especially for the regulatory troponin proteins [ 29, 30], the R21C mutation left shifted the Ca2+ sensitivity of force but only in the RV compared to RV-WT.

It should be kept in mind that some variants might only be polymorphisms with no clinical significance rather than pathogenic mutations, especially for genetic changes that have not been reported in the past.

Further functional tests, such as expression in eukaryotic cells, followed by measures of activation by DNA strand breaks, protein stability and interaction with cellular partners may be necessary to appreciate all effects of these mutations, especially for those where the in silico and in vitro conclusions differ.

In summary, for familial GC patients, we recommend screening of MSI status and CDH1 mutation especially for diffuse type GC.

However, the relevance of identified mutations, especially at position 183, for eIF3 interaction and translation cannot be excluded.

In order to assess the efficacy of the HRM approach to screen for mutations, especially in diagnosis, we first used two samples with previously known mutations, "2924delA and 3398delC".

Duplications and deletions are known to cause a number of genetic disorders, yet technical difficulties and financial considerations mean that screening for these mutations, especially duplications, is often not performed.

Second, the rarity of mutations, especially mutations that are beneficial for fitness, 6, 7 meant that it was experimentally difficult to obtain samples sizes compatible with testing hypotheses relating to mutation parameters.